The answer to this question is dependent on the drug in question. If you are taking a medication that will be incompatible with hemodialysis, then it should be withheld for 12 hours before the procedure. On the other hand, if you have taken a medication that has been deemed compatible with hemodialysis, then it can be withheld up until six hours beforehand.

This article discusses which type of drug to withhold before hemodialysis and how long one has to wait before undergoing their treatment based on whether or not they take medications that might pose an incompatibility risk during dialysis.

The discussion begins by providing examples of drugs that must never be given when someone is undergoing these procedures despite compatibility being maintained: acetaminophen, aspirin, diphenhydramine, and ibuprofen.

The article then provides a table of drugs that are compatible with hemodialysis followed by the time frame before which they can be given: non-steroidal anti-inflammatory medications (NSAIDs) such as naproxen or ketoprofen may be taken up to six hours beforehand -anticoagulants, analgesics/analgesic combinations, antitussives. These should not be withheld between one hour and three days prior to treatment. Hypnotics like zolpidem or benzodiazepines could also be administered up until four hours before dialysis without posing any risk for incompatibility with the process.

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